What eight studies say about choosing a somatic variant caller
Eight published somatic SNV and indel caller comparisons, read side by side: rankings change between studies, indel accuracy is lower, and no study covers FFPE, ctDNA or panels.
Tagged
#molecular-pathology
3 articles tagged with #molecular-pathology.
What the benchmarks say about choosing an RNA fusion caller
Short-read callers recover most validated driver fusions in haematologic cell lines but differ by orders of magnitude in review burden. Long-read callers score far lower in an independent benchmark. No comparison covers solid tumours or FFPE tissue.
Genomic Foundation Models in 2026: Two Ledgers, and What Survives a Held-Out Test Set
One pretrained genomic model can look dominant on a leaderboard and lose to a linear baseline on the next task. Two evidence ledgers explain why.
